Friday, October 21, 2016

Jalyn



Generic Name: dutasteride and tamsulosin (doo TAS ter ide and tam soo LOE sin)

Brand Names: Jalyn


What is dutasteride and tamsulosin?

Dutasteride prevents the conversion of testosterone to dihydrotestosterone (DHT) in the body. DHT is involved in the development of benign prostatic hyperplasia (BPH).


Tamsulosin is in a group of drugs called alpha-adrenergic (AL-fa ad-ren-ER-jik) blockers. Tamsulosin relaxes the muscles in the prostate and bladder neck, making it easier to urinate.


The combination of dutasteride and tamsulosin is used to treat benign prostatic hyperplasia (BPH) in men with an enlarged prostate.


Dutasteride and tamsulosin may also be used for purposes not listed in this medication guide.


What is the most important information I should know about dutasteride and tamsulosin?


You should not use this medication if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax). Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Dutasteride and tamsulosin should never be taken by a woman, a child, or a teenager. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride and tamsulosin capsules. This medication can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away. Do not donate blood while taking this medication and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride. Using dutasteride and tamsulosin may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using dutasteride and tamsulosin.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using dutasteride and tamsulosin before surgery unless your surgeon tells you to.


There are many other drugs that can interact with dutasteride and tamsulosin. Tell your doctor about all medications you use.

What should I discuss with my healthcare provider before taking dutasteride and tamsulosin?


You should not use this medication if you are allergic to dutasteride (Avodart) or tamsulosin (Flomax). Do not take dutasteride and tamsulosin if you are also taking alfuzosin (Uroxatral), doxazosin (Cardura), prazosin (Minipress), silodosin (Rapaflo), tamsulosin (Flomax), or terazosin (Hytrin). Dutasteride and tamsulosin should never be taken by a woman, a child, or a teenager. Dutasteride can be absorbed through the skin, and women or children should not be permitted to handle dutasteride and tamsulosin capsules.

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:



  • low blood pressure;




  • high blood pressure (hypertension);




  • liver disease;




  • severe kidney disease;




  • a history of prostate cancer; or




  • if you are allergic to sulfa drugs or to finasteride (Propecia, Proscar).




Using dutasteride and tamsulosin may increase your risk of developing prostate cancer. Your doctor will perform tests to make sure you do not have other conditions that would prevent you from safely using dutasteride and tamsulosin. Although dutasteride and tamsulosin is not for use by women, this medication can cause birth defects if a woman is exposed to it during pregnancy. Dutasteride and tamsulosin capsules should not be handled by a woman who is pregnant or who may become pregnant. If a woman accidentally comes into contact with this medication from a leaking capsule, wash the area with soap and water right away.

Tamsulosin can affect your pupils during cataract surgery. Tell your eye surgeon ahead of time that you are using this medication. Do not stop using dutasteride and tamsulosin before surgery unless your surgeon tells you to.


How should I take dutasteride and tamsulosin?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


Dutasteride and tamsulosin is usually taken once a day, approximately 30 minutes after a meal. Try to take this medication at the same time each day. Do not crush, chew, or open a dutasteride and tamsulosin capsule. Swallow it whole. A broken or leaking dutasteride and tamsulosin capsule can irritate your lips, mouth, or throat. Tamsulosin lowers blood pressure and may cause dizziness or fainting, especially when you first start taking dutasteride and tamsulosin. Call your doctor if you have severe dizziness or feel like you might pass out. It may take up to 6 months before your symptoms improve. Keep using the medication as directed and tell your doctor if your symptoms do not improve.

To be sure this medication is helping your condition and not causing harmful effects, your blood may need to be tested often. Your doctor will also test your prostate specific antigen (PSA) to check for prostate cancer. Visit your doctor regularly.


Store at room temperature away from moisture and heat. Do not use a capsule that has been exposed to high heat, which can cause the capsule to change shape or color.

See also: Jalyn dosage (in more detail)

What happens if I miss a dose?


Take the missed dose 30 minutes after your next meal. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


If you miss your doses for several days in a row, contact your doctor before restarting the medication. You may need a lower dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

Overdose symptoms may include extreme dizziness or fainting.


What should I avoid while taking dutasteride and tamsulosin?


Do not donate blood while taking this medication and for at least 6 months after your treatment ends. Dutasteride can be carried in the blood and could cause birth defects if a pregnant women receives a transfusion with blood that contains dutasteride. Dutasteride and tamsulosin may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.

Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.


Dutasteride and tamsulosin side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop taking this medication and call your doctor at once if you have a serious side effect such as:

  • feeling like you might pass out; or




  • penis erection that is painful or lasts 4 hours or longer.



Less serious side effects may include:



  • decreased libido (sex drive);




  • decreased amount of semen released during sex;




  • impotence (trouble getting or keeping an erection);




  • breast tenderness or enlargement;




  • mild dizziness; or




  • runny nose.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect dutasteride and tamsulosin?


Tell your doctor about all other medications you use, especially:



  • cimetidine (Tagamet);




  • conivaptan (Vaprisol);




  • cyclosporine (Gengraf, Neoral, Sandimmune);




  • imatinib (Gleevec);




  • isoniazid (for treating tuberculosis);




  • methimazole (Tapazole);




  • pioglitazone (Actos);




  • ropinirole (Requip);




  • ticlopidine (Ticlid);




  • a blood thinner such as warfarin (Coumadin, Jantoven);




  • an antibiotic such as clarithromycin (Biaxin), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), erythromycin (E.E.S., EryPed, Ery-Tab, Erythrocin, Pediazole), metronidazole (Flagyl, Protostat), telithromycin (Ketek), terbinafine (Lamisil), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);




  • an antidepressant such as clomipramine (Anafranil), desipramine (Norpramin), duloxetine (Cymbalta), fluoxetine (Prozac, Sarafem), nefazodone, paroxetine (Paxil), sertraline (Zoloft), tranylcypromine (Parnate), or trazodone (Desyrel, Oleptro);




  • antifungal medication such as fluconazole (Diflucan), itraconazole (Sporanox), ketoconazole (Nizoral), miconazole (Oravig), or voriconazole (Vfend);




  • anti-malaria medication such as chloroquine (Arelan) or pyrimethamine (Daraprim), or quinine (Qualaquin);




  • erectile dysfunction medicine such as sildenafil (Viagra), tadalafil (Cialis), or vardenafil (Levitra);




  • heart or blood pressure medication such as amiodarone (Cordarone, Pacerone), nicardipine (Cardene), or quinidine (Quin-G), and others;




  • HIV/AIDS medicine such as atazanavir (Reyataz), delavirdine (Rescriptor), efavirenz (Sustiva), fosamprenavir (Lexiva), indinavir (Crixivan), nelfinavir (Viracept), saquinavir (Invirase), or ritonavir (Norvir); or




  • medicine to treat psychiatric disorders, such as aripiprazole (Abilify), chlorpromazine (Thorazine), clozapine (Clozaril, FazaClo), fluphenazine (Permitil, Prolixin), haloperidol (Haldol), perphenazine (Trilafon), or thioridazine (Mellaril).




This list is not complete and there are many other drugs that can interact with dutasteride and tamsulosin. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.

More Jalyn resources


  • Jalyn Side Effects (in more detail)
  • Jalyn Dosage
  • Jalyn Use in Pregnancy & Breastfeeding
  • Jalyn Drug Interactions
  • Jalyn Support Group
  • 11 Reviews for Jalyn - Add your own review/rating


  • Jalyn Prescribing Information (FDA)

  • Jalyn Advanced Consumer (Micromedex) - Includes Dosage Information

  • Jalyn MedFacts Consumer Leaflet (Wolters Kluwer)

  • Jalyn Consumer Overview



Compare Jalyn with other medications


  • Benign Prostatic Hyperplasia


Where can I get more information?


  • Your pharmacist can provide more information about dutasteride and tamsulosin.

See also: Jalyn side effects (in more detail)


Thursday, October 20, 2016

Jantoven


Generic Name: warfarin (Oral route)

WAR-far-in

Oral route(Tablet)

Warfarin can cause major or fatal bleeding. Regular monitoring of INR should be performed on all treated patients. Drugs, dietary changes, and other factors affect INR levels achieved with warfarin sodium therapy. Instruct patients about prevention measures to minimize risk of bleeding and to report signs and symptoms of bleeding .



Commonly used brand name(s)

In the U.S.


  • Coumadin

  • Jantoven

Available Dosage Forms:


  • Tablet

Therapeutic Class: Anticoagulant


Chemical Class: Coumarin (class)


Uses For Jantoven


Warfarin is an anticoagulant. It is used to decrease the clotting ability of the blood and to help prevent harmful clots from forming in the blood vessels. It is often used to prevent or treat deep venous thrombosis, a condition in which harmful blood clots form in the blood vessels of the legs. These blood clots can travel to the lungs and cause a condition called pulmonary embolism. Warfarin is also used to prevent or treat blood clots that are caused by certain heart conditions or open-heart surgery. It may be used after a heart attack to prevent blood clots from forming. Although it will not dissolve blood clots that have already formed, warfarin may keep the clots from becoming larger and causing more serious problems.


This medicine is available only with your doctor's prescription.


Before Using Jantoven


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of warfarin in the pediatric population. Safety and efficacy have not been established.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of warfarin in the elderly. However, elderly patients may require caution and an adjustment in the dose, especially those who are at risk of bleeding.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersXStudies in animals or pregnant women have demonstrated positive evidence of fetal abnormalities. This drug should not be used in women who are or may become pregnant because the risk clearly outweighs any possible benefit.

Breast Feeding


Studies in women suggest that this medication poses minimal risk to the infant when used during breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Tamoxifen

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Abciximab

  • Acenocoumarol

  • Alteplase, Recombinant

  • Amiodarone

  • Anistreplase

  • Aprepitant

  • Aspirin

  • Bivalirudin

  • Capecitabine

  • Carboplatin

  • Celecoxib

  • Chamomile

  • Citalopram

  • Clopidogrel

  • Cyclophosphamide

  • Dabigatran Etexilate

  • Dalteparin

  • Danaparoid

  • Desvenlafaxine

  • Dipyridamole

  • Doxorubicin

  • Dronedarone

  • Drotrecogin Alfa

  • Enoxaparin

  • Eptifibatide

  • Escitalopram

  • Etoposide

  • Etravirine

  • Fenofibrate

  • Fenofibric Acid

  • Fish Oil

  • Fluconazole

  • Fluorouracil

  • Fluoxetine

  • Fluvoxamine

  • Garlic

  • Ginkgo

  • Imatinib

  • Infliximab

  • Influenza Virus Vaccine

  • Ketoprofen

  • Leflunomide

  • Lepirudin

  • Levofloxacin

  • Lycium

  • Marijuana

  • Mechlorethamine

  • Methotrexate

  • Methyl Salicylate

  • Metronidazole

  • Milnacipran

  • Moxifloxacin

  • Nandrolone

  • Naproxen

  • Noscapine

  • Oxandrolone

  • Papaya

  • Paroxetine

  • Phenindione

  • Phenprocoumon

  • Prasugrel

  • Procarbazine

  • Proguanil

  • Reteplase, Recombinant

  • Rivaroxaban

  • Ropinirole

  • Sertraline

  • Simvastatin

  • Sitaxsentan

  • St John's Wort

  • Streptokinase

  • Sulfamethoxazole

  • Sulfisoxazole

  • Tan-Shen

  • Tenecteplase

  • Testosterone

  • Ticlopidine

  • Tinzaparin

  • Tirofiban

  • Torsemide

  • Urokinase

  • Valproic Acid

  • Venlafaxine

  • Vilazodone

  • Vincristine

  • Vindesine

  • Voriconazole

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acarbose

  • Acemetacin

  • Acetaminophen

  • Allopurinol

  • Aminoglutethimide

  • Amitriptyline

  • Amoxicillin

  • Amprenavir

  • Apazone

  • Argatroban

  • Atovaquone

  • Avocado

  • Azathioprine

  • Azithromycin

  • Bee Pollen

  • Benorilate

  • Benzbromarone

  • Black Tea

  • Bosentan

  • Bromfenac

  • Butabarbital

  • Butalbital

  • Carbamazepine

  • Carbimazole

  • Cefamandole

  • Cefazolin

  • Chitosan

  • Chloral Hydrate

  • Cholestyramine

  • Choline Magnesium Trisalicylate

  • Chondroitin

  • Cimetidine

  • Ciprofloxacin

  • Cisapride

  • Clarithromycin

  • Coenzyme Q10

  • Colesevelam

  • Curcumin

  • Cyclosporine

  • Danazol

  • Darunavir

  • Desogestrel

  • Dexamethasone

  • Dexlansoprazole

  • Dextrothyroxine

  • Dicloxacillin

  • Dienogest

  • Diflunisal

  • Disopyramide

  • Disulfiram

  • Dong Quai

  • Doxepin

  • Drospirenone

  • Duloxetine

  • Enoxacin

  • Erlotinib

  • Erythromycin

  • Esomeprazole

  • Estradiol Cypionate

  • Estradiol Valerate

  • Eterobarb

  • Ethinyl Estradiol

  • Ethynodiol Diacetate

  • Etonogestrel

  • Exenatide

  • Felbamate

  • Fluoxymesterone

  • Fluvastatin

  • Gefitinib

  • Gemcitabine

  • Gemfibrozil

  • Ginger

  • Ginseng

  • Glucagon

  • Glucosamine

  • Glyburide

  • Green Tea

  • Griseofulvin

  • Heparin

  • Ifosfamide

  • Indomethacin

  • Indoprofen

  • Isoniazid

  • Isoxicam

  • Itraconazole

  • Ivermectin

  • Ketoconazole

  • Lactulose

  • Lansoprazole

  • Levamisole

  • Levonorgestrel

  • Levothyroxine

  • Liothyronine

  • Lopinavir

  • Lornoxicam

  • Medroxyprogesterone Acetate

  • Melatonin

  • Meloxicam

  • Menthol

  • Mephobarbital

  • Mercaptopurine

  • Mesalamine

  • Mesna

  • Mestranol

  • Methimazole

  • Methylprednisolone

  • Methyltestosterone

  • Methylthiouracil

  • Miconazole

  • Mitotane

  • Moricizine

  • Nafcillin

  • Nalidixic Acid

  • Nelfinavir

  • Nevirapine

  • Niacin

  • Nilutamide

  • Nimesulide

  • Norelgestromin

  • Norethindrone

  • Norfloxacin

  • Norgestimate

  • Norgestrel

  • Ofloxacin

  • Omeprazole

  • Orlistat

  • Oxyphenbutazone

  • Pantoprazole

  • Phenobarbital

  • Phenylbutazone

  • Phytonadione

  • Piracetam

  • Polyacrylamide

  • Potassium Iodide

  • Prednisone

  • Primidone

  • Propafenone

  • Propoxyphene

  • Propylthiouracil

  • Quetiapine

  • Ranitidine

  • Rifabutin

  • Rifampin

  • Rifapentine

  • Ritonavir

  • Rofecoxib

  • Rosuvastatin

  • Roxithromycin

  • Salicylamide

  • Salicylic Acid

  • Salsalate

  • Saquinavir

  • Secobarbital

  • Sodium Salicylate

  • Sodium Thiosalicylate

  • Sorafenib

  • Soybean

  • Soy Isoflavones

  • Soy Protein

  • Stanozolol

  • Sucralfate

  • Sulfasalazine

  • Sulfinpyrazone

  • Sulindac

  • Telithromycin

  • Tenidap

  • Terbinafine

  • Thyroglobulin

  • Thyroid

  • Tibolone

  • Ticlopidine

  • Tigecycline

  • Tolterodine

  • Tramadol

  • Trastuzumab

  • Trolamine Salicylate

  • Valdecoxib

  • Vancomycin

  • Vemurafenib

  • Vitamin A

  • Vitamin E

  • Vorinostat

  • Zafirlukast

  • Zileuton

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following is usually not recommended, but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Cranberry Juice

  • Pomegranate

Using this medicine with any of the following may cause an increased risk of certain side effects but may be unavoidable in some cases. If used together, your doctor may change the dose or how often you use this medicine, or give you special instructions about the use of food, alcohol, or tobacco.


  • Enteral Nutrition

  • High Protein Food

  • Noni Juice

  • Vitamin K Containing Food

Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Alcohol abuse, history of or

  • Mental disorders (e.g., psychosis or senility)—Patients with these conditions or those who cannot cooperate should not be given warfarin.

  • Blood disease or bleeding problems or

  • Heart infection or

  • Hypertension (high blood pressure) or

  • Spinal anesthesia, recent or

  • Stomach or intestinal ulcer, active or

  • Stroke or

  • Surgery, recent or scheduled (e.g., surgery of the eye, brain, or spine) or

  • Threatened miscarriage—Should not be used in patients with any of these conditions. The risk of bleeding from warfarin may be increased.

  • Catheter insertion or

  • Congestive heart failure or

  • Deep venous thrombosis, heparin-induced or

  • Diabetes or

  • Falls or blows to the body or head or

  • Infection or

  • Kidney disease or

  • Liver disease or

  • Major surgery, any type or

  • Protein C deficiency (rare hereditary disease), known or suspected or

  • Thrombocytopenia, heparin-induced or

  • Trauma—Use with caution. This medicine may increase your risk of having serious problems.

Proper Use of warfarin

This section provides information on the proper use of a number of products that contain warfarin. It may not be specific to Jantoven. Please read with care.


Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.


Carefully follow your doctor's instructions about any special diet. This medicine works best when you eat about the same amount of vitamin K in your food every day. Avoid big changes in how much vitamin K you eat. Some foods that have a high amount of vitamin K are asparagus, broccoli, brussels sprouts, cabbage, green leafy vegetables (such as collards, turnip greens, mustard greens, spinach, and salad greens), plums, rhubarb, and certain vegetable oils (such as soybean oil and canola oil).


Do not drink alcohol while you are using this medicine. Also avoid drinking cranberry juice or eating cranberry products.


You may take the tablets on a full or empty stomach.


This medicine should come with a Medication Guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets):
    • For prevention or treatment of blood clots:
      • Adult—At first, 2 to 5 milligrams (mg) per day. Your doctor will then adjust your dose up to a maximum of 10 mg per day depending on your condition.

      • Children—Use and dose must be determined by your doctor.



Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Jantoven


It is very important that your doctor check your progress at regular visits to see if the medicine is working properly. Blood tests, such as INR, are needed to check for proper dosage and unwanted side effects. Be sure to keep all appointments.


Using this medicine while you are pregnant can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using the medicine, tell your doctor right away.


Do not stop taking any of your medicines or start any new medicines unless they have been discussed with your doctor. Keep a list of your medicines with you at all times. This includes prescription medicines, nonprescription (over-the-counter [OTC]) medicines, and herbal or vitamin supplements.


Do not take other medicines that also contain warfarin. Using too much warfarin may cause serious bleeding problems.


Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery or medical tests.


Check with your doctor immediately if you start to have diarrhea, fever, or any signs of infection.


This medicine may cause skin necrosis or gangrene. Call your doctor right away if you have a pain, color change, or temperature change to any area of your body. Also, call your doctor right away if you have a pain in your toes and they look purple or dark in color. These could be signs of a serious medical problem.


This medicine may increase your chance of bleeding. Check with your doctor right away if you notice any unusual bleeding or bruising; black, tarry stools; blood in the urine or stools; or pinpoint red spots on your skin. Avoid picking your nose. If you need to blow your nose, blow it gently.


Be careful when using a regular toothbrush, dental floss, or toothpick. Your medical doctor, dentist, or nurse may recommend other ways to clean your teeth and gums. Check with your medical doctor before having any dental work done.


Be careful not to cut yourself when you are using sharp objects, such as a safety razor or fingernail or toenail cutters. Avoid contact sports or other situations where bruising or injury could occur.


It is recommended that you carry identification that says you are using warfarin. If you have any questions about what kind of identification to carry, check with your doctor.


Jantoven Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Less common
  • Abdominal or stomach pain with cramping

  • bleeding gums

  • blood in the urine

  • bloody stools

  • blurred vision

  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings

  • chest pain or discomfort

  • confusion

  • coughing up blood

  • difficulty with breathing or swallowing

  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

  • excessive bruising

  • headache

  • increased menstrual flow or vaginal bleeding

  • nosebleeds

  • paralysis

  • peeling of the skin

  • prolonged bleeding from cuts

  • red or black, tarry stools

  • red or dark brown urine

  • shortness of breath

  • sweating

  • unexplained swelling

  • unusual tiredness or weakness

Rare
  • Arm, back, or jaw pain

  • blue-green to black skin discoloration

  • blue or purple toes

  • change in consciousness

  • chest tightness or heaviness

  • chills

  • clay-colored stools

  • diarrhea

  • dizziness

  • fainting or loss of consciousness

  • fast or irregular breathing

  • fast or irregular heartbeat

  • fever

  • itching

  • light-colored stools

  • loss of appetite

  • nausea and vomiting

  • pain in the toes

  • pain, redness, or sloughing of the skin

  • pale skin

  • skin blisters

  • skin rash

  • small red or purple spots on the skin

  • stomach pain

  • swelling of the eyes or eyelids

  • tightness in the chest or wheezing

  • troubled breathing with exertion

  • unpleasant breath odor

  • unusual bleeding or bruising

  • upper right abdominal or stomach pain

  • vomiting of blood

  • yellow eyes and skin

Incidence not known
  • Painful or prolonged erection of the penis

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


Less common
  • Joint pain

  • muscle pain

Rare
  • Bloated

  • change in taste, or bad, unusual, or unpleasant (after) taste

  • cold intolerance

  • excess air or gas in the stomach or intestines

  • full feeling

  • general feeling of discomfort or illness

  • hair loss or thinning of the hair

  • hives or welts

  • lack or loss of strength

  • pain

  • passing gas

  • red, sore, or itching skin

  • sores, welting, or blisters

  • unusual drowsiness, dullness, or feeling of sluggishness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Jantoven side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Jantoven resources


  • Jantoven Side Effects (in more detail)
  • Jantoven Use in Pregnancy & Breastfeeding
  • Drug Images
  • Jantoven Drug Interactions
  • Jantoven Support Group
  • 1 Review for Jantoven - Add your own review/rating


  • Jantoven Prescribing Information (FDA)

  • Warfarin Prescribing Information (FDA)

  • Coumadin Prescribing Information (FDA)

  • Coumadin Monograph (AHFS DI)

  • Coumadin MedFacts Consumer Leaflet (Wolters Kluwer)

  • Coumadin Consumer Overview



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  • Deep Vein Thrombosis, First Event
  • Deep Vein Thrombosis, Recurrent Event
  • Heart Attack
  • Heart Failure
  • Prevention of Thromboembolism in Atrial Fibrillation
  • Prosthetic Heart Valves
  • Prosthetic Heart Valves, Mechanical Valves
  • Prosthetic Heart Valves, Tissue Valves
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JayCof-HC


Generic Name: chlorpheniramine, hydrocodone, and pseudoephedrine (KLOR fe NEER a meen, HYE droe KOE done, SOO doe ee FED rin)

Brand Names: Cordron-HC, Cordron-HC NR, Detuss, Hydrocof-HC, Hydron PCS, Hyphed, JayCof-HC, Notuss-Forte, P-V-Tussin Syrup, Q-V Tussin, Welltuss HC, Zutripro


What is JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?

Chlorpheniramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.


Hydrocodone is a narcotic cough medicine.


Pseudoephedrine is a decongestant that shrinks blood vessels in the nasal passages. Dilated blood vessels can cause nasal congestion (stuffy nose).


The combination of chlorpheniramine, hydrocodone, and pseudoephedrine is used to treat runny or stuffy nose, sinus congestion, and cough caused by the common cold or flu.


Chlorpheniramine, hydrocodone, and pseudoephedrine may also be used for purposes not listed in this medication guide.


What is the most important information I should know about JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?


Do not take this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use chlorpheniramine, hydrocodone, and pseudoephedrine before the MAO inhibitor has cleared from your body. Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine, hydrocodone, and pseudoephedrine. Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, hydrocodone, and pseudoephedrine. Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Never share hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.

What should I discuss with my healthcare provider before taking JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?


Do not take this medication if you have used an MAO inhibitor such as furazolidone (Furoxone), isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate) in the last 14 days. Serious, life threatening side effects can occur if you use chlorpheniramine, hydrocodone, and pseudoephedrine before the MAO inhibitor has cleared from your body. You should not use chlorpheniramine, hydrocodone, and pseudoephedrine if you are allergic to it.

To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:



  • asthma, COPD, sleep apnea, or other breathing disorder;



  • liver or kidney disease;


  • heart disease or high blood pressure;




  • diabetes;




  • a thyroid disorder;




  • curvature of the spine;




  • a history of head injury or brain tumor;




  • epilepsy or other seizure disorder;




  • low blood pressure;




  • glaucoma;




  • gallbladder disease;




  • Addison's disease or other adrenal gland disorders;




  • enlarged prostate, urination problems;




  • mental illness; or




  • a history of drug or alcohol addiction.




Hydrocodone may be habit-forming and should be used only by the person it was prescribed for. Never share hydrocodone with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it. FDA pregnancy category C. It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine will harm an unborn baby. Hydrocodone may cause addiction or withdrawal symptoms in a newborn if the mother takes the medication during pregnancy. Tell your doctor if you are pregnant or plan to become pregnant while using chlorpheniramine, hydrocodone, and pseudoephedrine. It is not known whether chlorpheniramine, hydrocodone, and pseudoephedrine passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.

How should I take JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.


You may take this medication with or without food.


Measure liquid medicine with a special dose-measuring spoon or cup, not a regular table spoon. If you do not have a dose-measuring device, ask your pharmacist for one.


Store at room temperature away from moisture and heat. Keep track of the amount of medicine used from each new bottle. Hydrocodone is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.

What happens if I miss a dose?


Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of hydrocodone can be fatal.

Overdose symptoms may include extreme drowsiness, feeling restless or nervous, vomiting, stomach pain, warmth or tingly feeling, seizure (convulsions), pinpoint pupils, confusion, cold and clammy skin, weak pulse, shallow breathing, fainting, or breathing that stops.


What should I avoid while taking JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?


Chlorpheniramine, hydrocodone, and pseudoephedrine may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Drinking alcohol can increase certain side effects of chlorpheniramine, hydrocodone, and pseudoephedrine.

JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have a serious side effect such as:

  • severe dizziness, anxiety, restless feeling, or nervousness;




  • fast, pounding, or uneven heartbeats;




  • shallow breathing, slow heartbeat;




  • confusion, hallucinations, unusual thoughts or behavior;




  • feeling like you might pass out;




  • urinating less than usual or not at all;




  • easy bruising or bleeding, unusual weakness, fever, chills, body aches, flu symptoms;




  • dangerously high blood pressure (severe headache, blurred vision, buzzing in your ears, chest pain, shortness of breath, seizure); or




  • upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).



Less serious side effects may include:



  • nausea, vomiting, upset stomach, constipation;




  • dry mouth;




  • blurred vision;




  • dizziness, drowsiness;




  • problems with memory or concentration;




  • sleep problems (insomnia);




  • ringing in your ears;




  • warmth, tingling, or redness under your skin; or




  • skin rash or itching.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect JayCof-HC (chlorpheniramine, hydrocodone, and pseudoephedrine)?


Before using this medication, tell your doctor if you regularly use other medicines that make you sleepy (such as cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression, or anxiety). They can add to sleepiness caused by chlorpheniramine, hydrocodone, and pseudoephedrine.

Tell your doctor about all other medications you use, especially:



  • blood pressure medication;




  • cimetidine (Tagamet);




  • rifampin (Rifadin, Rifater, Rifamate, Rimactane);




  • zidovudine (Retrovir, AZT);




  • an antidepressant;




  • a diuretic (water pill);




  • medication to treat irritable bowel syndrome;




  • bladder or urinary medications such as oxybutynin (Ditropan, Oxytrol) or tolterodine (Detrol);




  • aspirin or salicylates (such as Disalcid, Doan's Pills, Dolobid, Salflex, Tricosal, and others);




  • seizure medication such as phenytoin (Dilantin) or phenobarbital (Luminal, Solfoton);




  • a beta-blocker such as atenolol (Tenormin), carteolol (Cartrol), metoprolol (Lopressor, Toprol), nadolol (Corgard), propranolol (Inderal), sotalol (Betapace), timolol (Blocadren), and others; or




  • medicines to treat psychiatric disorders, such as chlorpromazine (Thorazine), haloperidol (Haldol), mesoridazine (Serentil), pimozide (Orap), or thioridazine (Mellaril).



This list is not complete and other drugs may interact with chlorpheniramine, hydrocodone, and pseudoephedrine. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More JayCof-HC resources


  • JayCof-HC Use in Pregnancy & Breastfeeding
  • JayCof-HC Drug Interactions
  • JayCof-HC Support Group
  • 0 Reviews for JayCof-HC - Add your own review/rating


  • Histinex PV Liquid MedFacts Consumer Leaflet (Wolters Kluwer)

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  • Zutripro Consumer Overview



Compare JayCof-HC with other medications


  • Cough and Nasal Congestion


Where can I get more information?


  • Your pharmacist can provide more information about chlorpheniramine, hydrocodone, and pseudoephedrine.


Wednesday, October 19, 2016

Janumet



Generic Name: sitagliptin and metformin (Oral route)


met-FOR-min hye-droe-KLOR-ide, sit-a-GLIP-tin FOS-fate


Oral route(Tablet)

Lactic acidosis is a rare, but serious complication that can occur due to metformin accumulation. The risk of lactic acidosis increases with conditions such as sepsis, dehydration, excessive alcohol intake, hepatic insufficiency, renal impairment, and acute congestive heart failure. Discontinue therapy and hospitalize the patient immediately for suspected lactic acidosis .



Commonly used brand name(s)

In the U.S.


  • Janumet

Available Dosage Forms:


  • Tablet

Therapeutic Class: Antidiabetic


Pharmacologic Class: Sitagliptin


Chemical Class: Metformin


Uses For Janumet


Metformin and sitagliptin combination is used to treat high blood sugar levels caused by type 2 diabetes. Normally, after you eat, your pancreas releases insulin to help your body store excess sugar for later use. This process occurs during normal digestion of food. In type 2 diabetes, your body does not work properly to store the excess sugar and the sugar remains in your blood. Chronic high blood sugar can lead to serious health problems in the future.


Proper diet is the first step in managing type 2 diabetes, but often medicines are needed to help your body. Metformin reduces the absorption of sugar, reduces the release of stored sugar from the liver, and helps your body's cells use sugar better. Sitagliptin helps to control blood sugar levels by increasing substances in the body that make the pancreas release more insulin. It also signals the liver to stop producing glucose when there is too much sugar in the blood.


Metformin and sitagliptin combination does not help patients who have insulin-dependent or type 1 diabetes, because they cannot produce insulin from their pancreas. Their blood glucose is best controlled by insulin injections.


This medicine is available only with your doctor's prescription.


Before Using Janumet


In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For this medicine, the following should be considered:


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to this medicine or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Appropriate studies have not been performed on the relationship of age to the effects of metformin and sitagliptin combination in the pediatric population. Safety and efficacy have not been established in children below 18 years of age.


Geriatric


Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of metformin and sitagliptin combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving metformin and sitagliptin combination.


Pregnancy








Pregnancy CategoryExplanation
All TrimestersBAnimal studies have revealed no evidence of harm to the fetus, however, there are no adequate studies in pregnant women OR animal studies have shown an adverse effect, but adequate studies in pregnant women have failed to demonstrate a risk to the fetus.

Breast Feeding


There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking this medicine, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.


  • Acetrizoic Acid

  • Diatrizoate

  • Ethiodized Oil

  • Iobenzamic Acid

  • Iobitridol

  • Iocarmic Acid

  • Iocetamic Acid

  • Iodamide

  • Iodipamide

  • Iodixanol

  • Iodohippuric Acid

  • Iodopyracet

  • Iodoxamic Acid

  • Ioglicic Acid

  • Ioglycamic Acid

  • Iohexol

  • Iomeprol

  • Iopamidol

  • Iopanoic Acid

  • Iopentol

  • Iophendylate

  • Iopromide

  • Iopronic Acid

  • Ioseric Acid

  • Iosimide

  • Iotasul

  • Iothalamate

  • Iotrolan

  • Iotroxic Acid

  • Ioversol

  • Ioxaglate

  • Ioxitalamic Acid

  • Ipodate

  • Metrizamide

  • Metrizoic Acid

  • Tyropanoate Sodium

Using this medicine with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acetazolamide

  • Alatrofloxacin

  • Balofloxacin

  • Cimetidine

  • Ciprofloxacin

  • Clinafloxacin

  • Dichlorphenamide

  • Dofetilide

  • Enoxacin

  • Fleroxacin

  • Flumequine

  • Gatifloxacin

  • Gemifloxacin

  • Grepafloxacin

  • Levofloxacin

  • Lomefloxacin

  • Moxifloxacin

  • Norfloxacin

  • Ofloxacin

  • Pefloxacin

  • Prulifloxacin

  • Rufloxacin

  • Sparfloxacin

  • Temafloxacin

  • Topiramate

  • Tosufloxacin

  • Trovafloxacin Mesylate

  • Zonisamide

Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Acebutolol

  • Alprenolol

  • Atenolol

  • Betaxolol

  • Bevantolol

  • Bisoprolol

  • Bitter Melon

  • Bucindolol

  • Carteolol

  • Carvedilol

  • Celiprolol

  • Cephalexin

  • Clorgyline

  • Dilevalol

  • Enalaprilat

  • Enalapril Maleate

  • Esmolol

  • Fenugreek

  • Glucomannan

  • Guar Gum

  • Iproniazid

  • Isocarboxazid

  • Labetalol

  • Levobunolol

  • Mepindolol

  • Metipranolol

  • Metoprolol

  • Moclobemide

  • Nadolol

  • Nebivolol

  • Nialamide

  • Oxprenolol

  • Pargyline

  • Penbutolol

  • Phenelzine

  • Pindolol

  • Procarbazine

  • Propranolol

  • Psyllium

  • Rifampin

  • Selegiline

  • Sotalol

  • Talinolol

  • Tertatolol

  • Timolol

  • Toloxatone

  • Tranylcypromine

  • Trospium

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Other Medical Problems


The presence of other medical problems may affect the use of this medicine. Make sure you tell your doctor if you have any other medical problems, especially:


  • Acid in the blood (diabetic ketoacidosis or metabolic acidosis) or

  • Kidney disease or

  • Type 1 diabetes—This medicine should not be used in patients with these conditions.

  • Alcohol intoxication or excessive use or

  • Underactive adrenal glands or

  • Underactive pituitary gland or

  • Undernourished condition or

  • Weakened physical condition or

  • Any other condition that causes low blood sugar—Patients with these conditions may be more likely to develop low blood sugar while taking sitagliptin and metformin combination.

  • Congestive heart failure, acute or

  • Dehydration, severe or

  • Heart or blood vessel problems or

  • Liver disease or

  • Sepsis (severe infection) or

  • Shock—These conditions can cause serious problems. If they happen, stop taking this medicine as soon as possible.

  • Fever or

  • Infection of any type or

  • Surgery (major) or

  • Trauma—These conditions may cause temporary problems with blood sugar control and your doctor may want to treat you with insulin.

  • Hypercholesterolemia (high cholesterol in the blood) or

  • Hypertriglyceridemia (high triglycerides and fats in the blood)

  • Obesity or

  • Pancreas problems, history of—Use with caution. May increase risk for pancreatitis (swelling of the pancreas).

  • Radiologic procedures (e.g., X-rays, CT scans, and MRIs) that require dyes to be injected in your vein—This medicine should be stopped before you have one of these procedures.

  • Vitamin B12 deficiency—This medicine may make this condition worse.

Proper Use of Janumet


Your doctor will tell you how much of this medicine to use and how often. Your dose may need to be changed several times in order to find out what works best for you. Do not use more medicine or use it more often than your doctor tells you to.


Metformin and sitagliptin combination should be taken with meals to help reduce any stomach upset.


This medicine should come with a medication guide. Read and follow these instructions carefully. Ask your doctor if you have any questions.


Carefully follow the special meal plan your doctor gave you. This is the most important part of controlling your diabetes, and is necessary if the medicine is to work properly. Exercise regularly and test for sugar in your blood or urine as directed.


Dosing


The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For oral dosage form (tablets):
    • For type 2 diabetes:
      • For patients taking metformin alone:
        • Adults—At first, 50 milligrams (mg) of sitagliptin, plus the dose of metformin already being taken, two times per day. Your doctor may gradually increase your dose until your blood sugar is controlled. If you are taking 850 mg of metformin two times per day, you may start with 50 mg of sitagliptin and 1000 mg of metformin two times per day.

        • Children—Use and dose must be determined by your doctor.


      • For patients taking sitagliptin alone:
        • Adults—At first, 50 milligrams (mg) of sitagliptin and 500 mg of metformin two times per day. Your doctor may gradually increase your dose until your blood sugar is controlled. However, the dose is usually not more than 50 mg of sitagliptin and 1000 mg of metformin two times per day.

        • Children—Use and dose must be determined by your doctor.


      • For patients using metformin and sitagliptin together as separate tablets:
        • Adults—The dose is the same as the dose you are already taking. Your doctor may gradually increase your dose until your blood sugar is controlled.

        • Children—Use and dose must be determined by your doctor.




Missed Dose


If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.


Storage


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Keep out of the reach of children.


Do not keep outdated medicine or medicine no longer needed.


Ask your healthcare professional how you should dispose of any medicine you do not use.


Precautions While Using Janumet


It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly. Blood and urine tests may be needed to check for unwanted effects.


Under certain conditions, too much metformin and sitagliptin can cause lactic acidosis. Symptoms of lactic acidosis are severe and quick to appear. They usually occur when other health problems not related to the medicine are present and are very severe, such as a heart attack or kidney failure. Symptoms of lactic acidosis include abdominal or stomach discomfort; decreased appetite; diarrhea; fast, shallow breathing; a general feeling of discomfort; muscle pain or cramping; and unusual sleepiness, tiredness, or weakness.


If symptoms of lactic acidosis occur, you should check your blood sugar and get immediate emergency medical help.


This medicine may cause hypoglycemia (low blood sugar). Low blood sugar can also occur if you delay or miss a meal or snack, exercise more than usual, drink alcohol, cannot eat because of nausea or vomiting, take certain medicines, or take this medicine with another type of diabetes medicine (e.g., insulin, glimepiride, or pioglitazone). Symptoms of low blood sugar must be treated before they cause you to pass out (unconsciousness). People feel different symptoms with low blood sugar. It is important that you learn which symptoms you usually have so you can treat it quickly.


Symptoms of low blood sugar include anxiety; behavior changes similar to being drunk; blurred vision; cold sweats; confusion; cool, pale skin; difficulty with thinking; drowsiness; excessive hunger; fast heartbeat; headaches that continue; nausea; nervousness; nightmares; restless sleep; shakiness; slurred speech; or unusual tiredness or weakness.


If symptoms of low blood sugar occur, eat glucose tablets or gel, corn syrup, honey, or sugar cubes; or drink fruit juice, non-diet soft drinks, or sugar dissolved in water. Also, check your blood for low blood sugar. Glucagon is used in emergency situations when severe symptoms such as seizures (convulsions) or unconsciousness occur. Have a glucagon kit available, along with a syringe and needle, and know how to use it. Members of your family should also know how to use it.


Hyperglycemia (high blood sugar) may occur if you do not take enough or skip a dose of your diabetes medicine, overeat or do not follow your diet plan, have a fever or infection, or do not exercise as much as usual.


Symptoms of high blood sugar include blurred vision; drowsiness; dry mouth; flushed, dry skin; fruit-like breath odor; increased urination (frequency and amount); ketones in the urine; loss of appetite; sleepiness; stomachache, nausea, or vomiting; tiredness; troubled breathing (rapid and deep); unconsciousness (passed out); or unusual thirst.


If symptoms of high blood sugar occur, check your blood sugar level and then call your doctor for instructions.


There may be a time when you need emergency help for a problem caused by your diabetes. You need to be prepared for these emergencies. It is a good idea to wear a medical identification (ID) bracelet or neck chain at all times. Also, carry an ID card in your wallet or purse that says you have diabetes and a list of all your medicines.


It is important to tell the doctor in charge that you are taking this medicine if you are going to have any medical or surgical procedures.


Pancreatitis may occur while you are using this medicine. Stop using this medicine and check with your doctor right away if you have a sudden and severe stomach pain, chills, constipation, nausea, vomiting, loss of appetite, fever, or lightheadedness.


This medicine may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; blistering, peeling, or loosening of the skin; fever or chills; trouble breathing or swallowing; or any swelling of your hands, face, or mouth while you are using this medicine.


Janumet Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor immediately if any of the following side effects occur:


Less common
  • Anxiety

  • blurred vision

  • chills

  • cold sweats

  • confusion

  • cool, pale skin

  • depression

  • dizziness

  • fast heartbeat

  • headache

  • increased hunger

  • loss of consciousness

  • mental cloudiness

  • nausea

  • nervousness

  • nightmares

  • not thinking clearly

  • seizures

  • shakiness

  • slurred speech

  • unusual tiredness or weakness

Rare
  • Abdominal or stomach discomfort

  • decreased appetite

  • diarrhea

  • fast, shallow breathing

  • general feeling of discomfort

  • muscle pain or cramping

  • shortness of breath

  • sleepiness

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Bloated

  • excess air or gas in the stomach or intestines

  • fever

  • full feeling

  • indigestion

  • lack or loss of strength

  • muscle aches

  • passing gas

  • sore throat

  • stuffy or runny nose

  • vomiting

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: Janumet side effects (in more detail)



The information contained in the Thomson Reuters Micromedex products as delivered by Drugs.com is intended as an educational aid only. It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs (including any herbal medicines or supplements) or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you.


The use of the Thomson Reuters Healthcare products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Thomson Reuters Healthcare and Drugs.com make no representation or warranty as to the accuracy, reliability, timeliness, usefulness or completeness of any of the information contained in the products. Additionally, THOMSON REUTERS HEALTHCARE MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Thomson Reuters Healthcare does not assume any responsibility or risk for your use of the Thomson Reuters Healthcare products.


More Janumet resources


  • Janumet Side Effects (in more detail)
  • Janumet Dosage
  • Janumet Use in Pregnancy & Breastfeeding
  • Drug Images
  • Janumet Drug Interactions
  • Janumet Support Group
  • 19 Reviews for Janumet - Add your own review/rating


  • Janumet Prescribing Information (FDA)

  • Janumet MedFacts Consumer Leaflet (Wolters Kluwer)

  • Janumet Consumer Overview



Compare Janumet with other medications


  • Diabetes, Type 2

Junel Fe 1/20


Generic Name: ethinyl estradiol and norethindrone (ETH in il ess tra DYE ole and nor ETH in drone)

Brand Names: Aranelle, Balziva, Brevicon, Briellyn, Cyclafem 1/35, Cyclafem 7/7/7, Estrostep Fe, Femcon FE, Generess Fe, Gildess FE 1.5/0.03, Gildess FE 1/0.2, Junel 1.5/30, Junel 1/20, Junel Fe 1.5/30, Junel Fe 1/20, Leena, Lo Loestrin Fe, Loestrin 21 1.5/30, Loestrin 21 1/20, Loestrin 24 Fe, Loestrin Fe 1.5/30, Loestrin Fe 1/20, Microgestin 1.5/30, Microgestin 1/20, Microgestin FE 1.5/30, Microgestin FE 1/20, Modicon, Necon 0.5/35, Necon 1/35, Necon 10/11, Necon 7/7/7, Norinyl 1+35, Nortrel 0.5/35, Nortrel 1/35, Nortrel 7/7/7, Ortho-Novum 1/35, Ortho-Novum 7/7/7, Ovcon 35, Ovcon 35 Fe, Ovcon 50, Tilia Fe, Tri-Legest Fe, Tri-Norinyl, Zenchent Fe, Zeosa


What is Junel Fe 1/20 (ethinyl estradiol and norethindrone)?

Ethinyl estradiol and norethindrone contains a combination of female hormones that prevent ovulation (the release of an egg from an ovary). This medication also causes changes in your cervical mucus and uterine lining, making it harder for sperm to reach the uterus and harder for a fertilized egg to attach to the uterus.


Ethinyl estradiol and norethindrone are used as contraception to prevent pregnancy. It is also used to treat severe acne.


Ethinyl estradiol and norethindrone may also be used for purposes not listed in this medication guide.


What is the most important information I should know about Junel Fe 1/20 (ethinyl estradiol and norethindrone)?


Do not use birth control pills if you are pregnant or if you have recently had a baby. Do not use this medication if you have any of the following conditions: a history of stroke or blood clot, circulation problems, a hormone-related cancer such as breast or uterine cancer, abnormal vaginal bleeding, liver disease or liver cancer, or a history of jaundice caused by birth control pills.

You may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication. Follow your doctor's instructions.


Taking hormones can increase your risk of blood clots, stroke, or heart attack, especially if you smoke and are older than 35.

Some drugs can make birth control pills less effective, which may result in pregnancy. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.


What should I discuss with my healthcare provider before taking Junel Fe 1/20 (ethinyl estradiol and norethindrone)?


This medication can cause birth defects. Do not use if you are pregnant. Tell your doctor right away if you become pregnant, or if you miss two menstrual periods in a row. If you have recently had a baby, wait at least 4 weeks before taking birth control pills (6 weeks if you are breast-feeding). You should not take birth control pills if you have:

  • coronary artery disease, a severe or uncontrolled heart valve disorder, untreated or uncontrolled high blood pressure;




  • a history of a stroke, blood clot, or circulation problems;




  • a hormone-related cancer such as breast or uterine cancer;




  • unusual vaginal bleeding that has not been checked by a doctor;




  • liver disease or liver cancer;




  • severe migraine headaches; or




  • a history of jaundice caused by pregnancy or birth control pills.



To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:



  • high blood pressure or a history of heart disease;




  • high cholesterol, gallbladder disease, or diabetes;




  • migraine headaches or a history of depression; or




  • a history of breast cancer or an abnormal mammogram.




The hormones in birth control pills can pass into breast milk and may harm a nursing baby. This medication may also slow breast milk production. Do not use if you are breast-feeding a baby.

How should I take Junel Fe 1/20 (ethinyl estradiol and norethindrone)?


Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Take your first pill on the first day of your period or on the first Sunday after your period begins (follow your doctor's instructions).


You may need to use back-up birth control, such as condoms or a spermicide, when you first start using this medication. Follow your doctor's instructions.


The 28-day birth control pack contains seven "reminder" pills to keep you on your regular cycle. Your period will usually begin while you are using these reminder pills.


You may have breakthrough bleeding, especially during the first 3 months. Tell your doctor if this bleeding continues or is very heavy.

Take one pill every day, no more than 24 hours apart. When the pills run out, start a new pack the following day. You may get pregnant if you do not use this medication regularly. Get your prescription refilled before you run out of pills completely.


The chewable tablet may be chewed or swallowed whole. If chewed, drink a full glass of water just after you swallow the pill.


If you need surgery or medical tests or if you will be on bed rest, you may need to stop using this medication for a short time. Any doctor or surgeon who treats you should know that you are using birth control pills.


Your doctor will need to check your progress on a regular basis. Do not miss any scheduled appointments.


Store at room temperature away from moisture and heat.

What happens if I miss a dose?


Missing a pill increases your risk of becoming pregnant. If you miss one "active" pill, take two pills on the day that you remember. Then take one pill per day for the rest of the pack.


If you miss two "active" pills in a row in week one or two, take two pills per day for two days in a row. Then take one pill per day for the rest of the pack. Use back-up birth control for at least 7 days following the missed pills.


If you miss two "active" pills in a row in week three, or if you miss three pills in a row during any of the first 3 weeks, throw out the rest of the pack and start a new one the same day if you are a Day 1 starter. If you are a Sunday starter, keep taking a pill every day until Sunday. On Sunday, throw out the rest of the pack and start a new one that day.


If you miss two or more pills, you may not have a period during the month. If you miss a period for two months in a row, call your doctor because you might be pregnant.

If you miss any reminder pills, throw them away and keep taking one pill per day until the pack is empty. You do not need back-up birth control if you miss a reminder pill.


What happens if I overdose?


Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include nausea, vomiting, and vaginal bleeding.

What should I avoid while taking Junel Fe 1/20 (ethinyl estradiol and norethindrone)?


Do not smoke while using birth control pills, especially if you are older than 35. Smoking can increase your risk of blood clots, stroke, or heart attack caused by birth control pills.

Birth control pills will not protect you from sexually transmitted diseases--including HIV and AIDS. Using a condom is the only way to protect yourself from these diseases.


Junel Fe 1/20 (ethinyl estradiol and norethindrone) side effects


Get emergency medical help if you have any of these signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. Stop using this medication and call your doctor at once if you have any of these serious side effects:

  • sudden numbness or weakness, especially on one side of the body;




  • sudden severe headache, confusion, problems with vision, speech, or balance;




  • sudden cough, wheezing, rapid breathing, coughing up blood;




  • pain, swelling, warmth, or redness in one or both legs;




  • chest pain or heavy feeling, pain spreading to the arm or shoulder, nausea, sweating, general ill feeling;




  • a change in the pattern or severity of migraine headaches;




  • pain in your upper stomach, jaundice (yellowing of the skin or eyes);




  • a lump in your breast;




  • swelling in your hands, ankles, or feet; or




  • symptoms of depression (sleep problems, weakness, mood changes).



Less serious side effects may include:



  • mild nausea or vomiting, appetite or weight changes;




  • breast swelling or tenderness;




  • headache, nervousness, dizziness;




  • problems with contact lenses;




  • freckles or darkening of facial skin, loss of scalp hair; or




  • vaginal itching or discharge.



This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.


What other drugs will affect Junel Fe 1/20 (ethinyl estradiol and norethindrone)?


Some drugs can make ethinyl estradiol and norethindrone less effective, which may result in pregnancy. Before using ethinyl estradiol and norethindrone, tell your doctor if you are using any of the following drugs:



  • acetaminophen (Tylenol) or ascorbic acid (vitamin C);




  • bosentan (Tracleer);




  • prednisolone (Orapred);




  • St. John's wort;




  • theophylline (Elixophyllin, Theo-24, Uniphyl);




  • an antibiotic;




  • HIV or AIDS medications;




  • phenobarbital (Solfoton) and other barbiturates; or




  • seizure medication.



This list is not complete and other drugs may interact with birth control pills. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.



More Junel Fe 1/20 resources


  • Junel Fe 1/20 Side Effects (in more detail)
  • Junel Fe 1/20 Use in Pregnancy & Breastfeeding
  • Drug Images
  • Junel Fe 1/20 Drug Interactions
  • Junel Fe 1/20 Support Group
  • 10 Reviews for Junel Fe/20 - Add your own review/rating


  • Aranelle Prescribing Information (FDA)

  • Balziva Prescribing Information (FDA)

  • Brevicon Prescribing Information (FDA)

  • Briellyn Prescribing Information (FDA)

  • Cyclafem 1/35 Prescribing Information (FDA)

  • Cyclafem 7/7/7 Prescribing Information (FDA)

  • Estrostep Fe Prescribing Information (FDA)

  • Femcon FE Prescribing Information (FDA)

  • Femcon Fe Chewable Tablets MedFacts Consumer Leaflet (Wolters Kluwer)

  • Femhrt Consumer Overview

  • Femhrt Prescribing Information (FDA)

  • Femhrt MedFacts Consumer Leaflet (Wolters Kluwer)

  • Jevantique Prescribing Information (FDA)

  • Jinteli Prescribing Information (FDA)

  • Leena Prescribing Information (FDA)

  • Lo Loestrin Fe MedFacts Consumer Leaflet (Wolters Kluwer)

  • Lo Loestrin Fe Consumer Overview

  • Lo Loestrin Fe Advanced Consumer (Micromedex) - Includes Dosage Information

  • Lo Loestrin Fe Prescribing Information (FDA)

  • Loestrin 24 FE Prescribing Information (FDA)

  • Loestrin 24 Fe Consumer Overview

  • Loestrin Fe 1/20 MedFacts Consumer Leaflet (Wolters Kluwer)

  • Ovcon 35 MedFacts Consumer Leaflet (Wolters Kluwer)

  • Tilia FE Prescribing Information (FDA)

  • Tri-Norinyl Prescribing Information (FDA)

  • Zenchent FE Prescribing Information (FDA)

  • Zeosa Prescribing Information (FDA)



Compare Junel Fe 1/20 with other medications


  • Abnormal Uterine Bleeding
  • Acne
  • Birth Control
  • Endometriosis
  • Gonadotropin Inhibition
  • Menstrual Disorders
  • Polycystic Ovary Syndrome
  • Postmenopausal Symptoms
  • Prevention of Osteoporosis


Where can I get more information?


  • Your pharmacist can provide more information about ethinyl estradiol and norethindrone.

See also: Junel Fe/20 side effects (in more detail)


Tuesday, October 18, 2016

Jolivette Oral, Implantation, Parenteral


Generic Name: progestin contraceptives (Oral route, Parenteral route)


Commonly used brand name(s)

In the U.S.


  • Aygestin

  • Camila

  • Errin

  • Jolivette

  • Next Choice

  • Nora-BE

  • Nor-QD

  • Ortho Micronor

  • Ovrette

  • Plan B

  • Plan B One-Step

  • Provera

Available Dosage Forms:


  • Tablet

Uses For Jolivette


Progestins are hormones.


The low-dose progestins for contraception are used to prevent pregnancy. Other names for progestin-only oral contraceptives are minipills and progestin-only pills (POPs). Progestins can prevent fertilization by preventing a woman's egg from fully developing.


Also, progestins cause changes at the opening of the uterus, such as thickening of the cervical mucus. This makes it hard for the partner's sperm to reach the egg. The fertilization of the woman's egg with her partner's sperm is less likely to occur while she is taking, receiving, or using a progestin, but it can occur. Even so, the progestins make it harder for the fertilized egg to become attached to the walls of the uterus, making it difficult to become pregnant.


No contraceptive method is 100 percent effective. Studies show that fewer than 1 of each 100 women become pregnant during the first year of use after correctly receiving the injection on time. Fewer than 10 of each 100 women who take progestins correctly by mouth for contraception become pregnant during the first year of use. Methods that do not work as well include condoms, diaphragms, or spermicides. Discuss with your doctor what your options are for birth control.


Progestin contraceptives are available only with your doctor's prescription.


Importance of Diet


Make certain your doctor knows if you are on any special diet, such as a low-sodium or low-sugar diet.


Before Using Jolivette


Allergies


Tell your doctor if you have ever had any unusual or allergic reaction to medicines in this group or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.


Pediatric


Progestins have been used by teenagers and have not been shown to cause different side effects or problems than they do in adults. You must take progestin-only oral contraceptives every day in order for them to work. Progestins do not protect against sexually transmitted diseases, a risk factor for teenagers. It is not known if Depo-Provera Contraceptive Injection causes problems with bone development and growth in teenagers and young women. It is important that your doctor check you regularly for growth problems, especially if you have been using this medicine for 2 years or longer.


Geriatric


This medicine has been tested and has not been shown to cause different side effects or problems in older people than it does in younger adults.


Pregnancy


Use of progestin-only contraceptives during pregnancy is not recommended. Doctors should be told if pregnancy is suspected. When accidently used during pregnancy, progestins used for contraception have not caused problems.


Breast Feeding


Although progestins pass into the breast milk, the low doses of progestins used for contraception have not been shown to cause problems in nursing babies. Progestins used for contraception are recommended for nursing mothers when contraception is desired.


Interactions with Medicines


Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking any of these medicines, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.


Using medicines in this class with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.


  • Isotretinoin

  • Theophylline

  • Tizanidine

  • Tranexamic Acid

Interactions with Food/Tobacco/Alcohol


Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.


Other Medical Problems


The presence of other medical problems may affect the use of medicines in this class. Make sure you tell your doctor if you have any other medical problems, especially:


  • Asthma or

  • Epilepsy, or history of or

  • Heart or circulation problems or

  • Kidney disease, severe or

  • Migraine headaches—May cause fluid buildup and make these conditions worse.

  • Bleeding problems, undiagnosed, such as blood in the urine or changes in vaginal bleeding—May make diagnosis of these problems more difficult.

  • Breast disease (e.g., breast lumps or cysts), history of—May make this condition worse in certain types of diseases that do not react to progestins in a positive way.

  • Central nervous system (CNS) disorders (e.g., depression), or history of or

  • High blood cholesterol or

  • Osteoporosis (brittle bones), or a family history of—May cause these conditions to occur or make these conditions worse.

  • Diabetes mellitus—May cause a mild increase in blood sugar and a need to monitor blood sugar more often.

  • Liver disease—The effects of some progestins may be increased. May make this condition worse.

Proper Use of progestin contraceptives

This section provides information on the proper use of a number of products that contain progestin contraceptives. It may not be specific to Jolivette. Please read with care.


To make the use of a progestin as safe and reliable as possible, you should understand how and when to take it and what effects may be expected. Progestins for contraception usually come with patient directions. Read them carefully before taking or using this medicine.


Progestins do not protect a woman from sexually transmitted diseases (STDs), including human immunodeficiency virus (HIV), or acquired immunodeficiency syndrome (AIDS). The use of latex (rubber) condoms or abstinence is recommended for protection from these diseases.


Take this medicine only as directed by your doctor. Do not take more of it and do not take it for a longer time than your doctor ordered. To do so may increase the chance of side effects. Try to take the medicine at the same time each day to reduce the possibility of side effects and to allow it to work better.


When using levonorgestrel tablet dosage form for emergency contraception:


  • The tablets may be taken at any time during the menstrual cycle.

When using medroxyprogesterone injection dosage form for contraception:


  • Your injection is given by a health care professional every 3 months.

  • To stop using medroxyprogesterone injection for contraception, simply do not have another injection.

  • Full protection from pregnancy begins immediately if you receive the first injection within the first 5 days of your menstrual period or within 5 days after delivering a baby if you will not be breast-feeding. If you are going to breast-feed, you may have to wait for 6 weeks from your delivery date before receiving your first injection. If you follow this schedule, you do not need to use another form of birth control. Protection from that one injection ends at 3 months. You will need another injection every 3 months to have full protection from becoming pregnant. However, if the injection is given later than 5 days from the first day of your last menstrual period, you will need to use another method of birth control as directed by your doctor.

When using an oral progestin dosage form:


  • Take a tablet every 24 hours each day of the year. Taking the medicine at the same time each day helps to reduce the possibility of side effects and makes it work as expected. Taking your tablet 3 hours late is the same as missing a dose and can cause the medicine to not work properly.

  • Keep the tablets in the container in which you received them to help you to keep track of your dosage schedule.

  • When switching from estrogen and progestin oral contraceptives, you should take the first dose of the progestin-only contraceptive the next day after the last active pill of the estrogen and progestin oral contraceptive has been taken. This means you will not take the last 7 days (placebo or nonactive pills) of a 28-day cycle of the estrogen and progestin oral contraceptive pack. You will begin a new pack of progestin-only birth control pills on the 22nd day.

  • Also, when switching, full protection from pregnancy begins after 48 hours if the first dose of the progestin-only contraceptive is taken on the first day of the menstrual period. If the birth control is begun on other days, full protection may begin 3 weeks after you begin taking the medicine for the first time. You should use a second method of birth control for at least the first 3 weeks to ensure full protection. You are not fully protected if you miss pills. The chances of your getting pregnant are greater with each pill that is missed.

Follow your doctor's orders to schedule the proper time to receive an injection of progestins for contraception.


Dosing


The dose medicines in this class will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of these medicines. If your dose is different, do not change it unless your doctor tells you to do so.


The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.


  • For levonorgestrel

  • For oral dosage form (tablets):
    • For emergency contraception for preventing pregnancy:
      • Adults and teenagers—The first dose of 0.75 milligram should be taken as soon as possible within 72 hours of intercourse. The second dose must be taken 12 hours later.



  • For medroxyprogesterone

  • For muscular injection dosage form
    • For preventing pregnancy:
      • Adults and teenagers—150 milligrams injected into a muscle in the upper arm or in the buttocks every three months (13 weeks).



  • For subcutaneous injection dosage form
    • For preventing pregnancy:
      • Adults and teenagers—104 milligrams injected under the skin of the anterior thigh or abdomen every three months (12 to 14 weeks).



  • For norethindrone

  • For oral dosage form (tablets):
    • For preventing pregnancy:
      • Adults and teenagers—0.35 milligrams every 24 hours, beginning on the first day of your menstrual cycle whether menstrual bleeding begins or not. The first day of your menstrual cycle can be figured out by counting 28 days from the first day of your last menstrual cycle.



  • For norgestrel

  • For oral dosage form (tablets):
    • For preventing pregnancy:
      • Adults and teenagers—75 micrograms every 24 hours, beginning on the first day of your menstrual cycle whether menstrual bleeding occurs or not. The first day of your menstrual cycle can be figured out by counting 28 days from the first day of your last menstrual cycle.



Missed Dose


Call your doctor or pharmacist for instructions.


For oral dosage form (tablets):


  • When you miss 1 day's dose of oral tablets or are 3 hours or more late in taking your dose, many doctors recommend that you take the missed dose immediately, continue your normal schedule, and use another method of contraception for 2 days. This is different from what is done after a person misses a dose of birth control tablets that contain more than one hormone.

For injection dosage form:


  • If you miss having your next injection and it has been longer than 13 weeks since your last injection, your doctor may want you to stop receiving the medicine. Use another method of birth control until your period begins or until your doctor determines that you are not pregnant.

  • If your doctor has other directions, follow that advice. Any time you miss a menstrual period within 45 days after a missed or delayed dose you will need to be tested for a possible pregnancy.

Storage


Keep out of the reach of children.


Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.


Do not keep outdated medicine or medicine no longer needed.


Precautions While Using Jolivette


It is very important that your doctor check your progress at regular visits. This will allow your dosage to be adjusted to your changing needs, and will allow any unwanted effects to be detected. These visits are usually every 12 months when you are taking progestins by mouth for birth control.


  • If you are receiving the medroxyprogesterone injection for contraception, a physical exam is needed only every 12 months, but you need an injection every 3 months. Your doctor will also want to check you for any bone development or growth problems, especially if you are a teenager or young adult.

Progestins may cause dizziness in some people. Make sure you know how you react to this medicine before you drive, use machines, or do anything else that could be dangerous if you are not alert.


It is possible that certain doses of progestins may cause a temporary thinning of the bones by changing your hormone balance. It is important that your doctor know if you have an increased risk of osteoporosis. Some things that can increase your risk for osteoporosis include cigarette smoking, abusing alcohol, taking or drinking large amounts of caffeine, and having a family history of osteoporosis or easily broken bones. Some medicines, such as steroids (cortisone-like medicines) or anticonvulsants (seizure medicines), can also cause thinning of the bones. It is especially important that you tell your doctor about any of these risk factors if you are taking Depo-Provera® Contraceptive Injection or Depo-SubQ Provera® 104. These contraceptives may cause a loss of bone mineral density. Your doctor may replace these contraceptives with a different one.


Vaginal bleeding of various amounts may occur between your regular menstrual periods during the first 3 months of use. This is not unusual and does not mean you should stop the medicine. This is sometimes called spotting when the bleeding is slight, or breakthrough bleeding when it is heavier. If this occurs, continue on your regular dosing schedule. Check with your doctor:


  • If vaginal bleeding continues for an unusually long time.

  • If your menstrual period has not started within 45 days of your last period.

Missed menstrual periods may occur. If you suspect a pregnancy, you should call your doctor immediately.


If you are scheduled for any laboratory tests, tell your doctor that you are taking a progestin. Progestins can change certain test results.


The following medicines might reduce the effectiveness of progestins for contraception:


  • Aminoglutethimide (e.g., Cytadren®)

  • Carbamazepine (e.g., Tegretol®)

  • Phenobarbital

  • Phenytoin (e.g., Dilantin®)

  • Rifabutin (e.g., Mycobutin®)

  • Rifampin (e.g., Rifadin®)

Sometimes your doctor may use these medicines with progestins for contraception, but the doctor will give you special directions to follow to make sure your progestin is working properly. In order to prevent pregnancy, use a second method of birth control together with the progestin when you also use a medicine that could reduce the effectiveness of the progestin. If you are using medroxyprogesterone injection for contraception, continue using a back-up method of birth control until you have your next injection, even if the medicine that affects contraceptives is discontinued. If you are using the oral tablets, continue using a back-up method of birth control for a full cycle (or 4 weeks), even if the medicine that affects contraceptives is discontinued.


If you vomit your oral progestin-only contraceptive for any reason within a few hours after taking it, do not take another dose. Return to your regular dosing schedule and use an additional back-up method of birth control for 48 hours.


If you are receiving levonorgestrel tablets for emergency contraception and vomiting occurs within 1 hour after taking either dose of the medicine, contact your physician to discuss whether the dose should be repeated.


Jolivette Side Effects


Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.


Check with your doctor as soon as possible if any of the following side effects occur:


More common
  • Changes in uterine bleeding (increased amounts of menstrual bleeding occurring at regular monthly periods

  • heavier uterine bleeding between regular monthly periods

  • lighter uterine bleeding between menstrual periods

  • or stopping of menstrual periods

Less common
  • Mental depression

  • skin rash

  • unexpected or increased flow of breast milk

Incidence not known - for patients taking Depo-Provera Contraceptive Injection
  • Cough

  • decrease in height

  • difficulty swallowing

  • fast heartbeat

  • hives, itching, puffiness, or swelling of the eyelids or around the eyes, face, lips or tongue

  • pain in back, ribs, arms, or legs

  • pain or swelling in arms or legs without any injury

  • shortness of breath

  • skin rash

  • tightness in chest

  • wheezing

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:


More common
  • Abdominal pain or cramping

  • diarrhea

  • dizziness

  • fatigue

  • mild headache

  • mood changes

  • nausea

  • nervousness

  • pain or irritation at the injection site

  • swelling of face, ankles, or feet

  • unusual tiredness or weakness

  • vomiting

  • weight gain

Less common
  • Acne

  • breast pain or tenderness

  • brown spots on exposed skin, possibly long-lasting

  • hot flashes

  • loss or gain of body, facial, or scalp hair

  • loss of sexual desire

  • trouble in sleeping

Not all of the side effects listed above have been reported for each of these medicines, but they have been reported for at least one of them. All of the progestins are similar, so any of the above side effects may occur with any of these medicines.


After you stop using this medicine, your body may need time to adjust. The length of time this takes depends on the amount of medicine you were using and how long you used it. During this period of time, check with your doctor if you notice any of the following side effects:


  • Delayed return to fertility

  • stopping of menstrual periods

  • unusual menstrual bleeding (continuing)

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.


Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.



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